Pure Lab Vitamins Magnesium Glycinate Nighttime caps are NHPD approved for the following claims:
• Helps increase the total sleep time (aspect of sleep quality) in people suffering from sleep restriction or
altered sleep schedule e.g. shift work and jet lag
• Helps relieve the daytime fatigue associated with jet lag
• Helps to reduce the time it takes to fall asleep (sleep onset latency aspect of sleep quality) in people
with delayed sleep phase syndrome
• Helps re-set the body's sleep-wake cycle (aspect of the circadian rhythm)
Insomnia, Shift work, Jet lag:
Melatonin helps regulate the circadian rhythm, the day-night cycle.
In the body it is naturally synthesized from the amino acid tryptophan and its production is influenced by information received from the retina in the eye, about the daily patterns of light and darkness.
Generally, the production of melatonin is inhibited by light and permitted by darkness. For this reason melatonin has been called: the hormone of darkness.
The secretion of melatonin peaks in the middle of the night and gradually falls during the second half of the night. Even low light levels can diminish melatonin production to some extent.
Light emitted from todays omni-present electronic screens can alter these natural patterns and influence the circadian rhythm.
There is evidence that circadian rhythms in humans may be disrupted by exposure to electromagnetic fields from power lines, appliances, screens and cellular phones. Altered neural function from exposure to extremely low frequency fields (found near high-voltage power lines) and suppressed melatonin levels have been reported.
Melatonin increases the amount of sleep in people after working night shifts.
Melatonin has been used since the 1970's to reduce the effects of jet lag, by promoting the necessary re-set of the body's sleep-wake phase. Proper dose timing is crucial, however, it can otherwise prolong adaption.
Magnesium and melatonin work together.
Magnesium helps in the body’s produce melatonin, but also think of magnesium as the body’s relaxer - of muscle and mind.
Magnesium suppresses the release of stimulating catecholamines.
This means magnesium deficiency leads to more stimulation = less relaxation.
You will find more information in the Research Tab of our Magnesium Glycinate product info.
Antioxidant and Free Radical Scavenger:
Besides its function as synchronizer of the biological clock, melatonin is a powerful free-radical scavenger and wide-spectrum antioxidant as discovered in 1993.
Melatonin is an antioxidant that can easily cross cell membranes and the blood–brain barrier.
Melatonin has been proven to be twice as active as vitamin E, believed to be the most effective lipophilic antioxidant.
Also different from other classic antioxidants, such as vitamin C and vitamin E, melatonin has amphiphilic properties, which means it is active in fatty tissues and watery systems, like blood and lymph.
According to a 2009 review, published in the American Academy of Pediatrics’ Journal: “Pediatrics in Review,” roughly 29 percent of children with ADHD who receive ongoing treatment with stimulant medication have significant sleep disturbances.
Children who take the ADHD medication methylphenidate have a particularly high rate of sleep problems, and fully 54 to 64 percent of these children experience symptoms of insomnia.
And a growing number of physicians prescribe melatonin at therapeutic doses to help these children maintain a healthy sleep rhythm.
Short and longterm studies.[10,11,12,13] showed Melatonin to be safe and to significantly improve sleep onset and sleep duration.
Sleep hygiene is most important.
This includes a consistent routine, a dark and quiet sleep space, avoiding hunger (and eating) prior to bedtime, relaxation techniques before bed, strict avoidance of television, computers, handheld devices and video games, and encouraging reading prior to bedtime.
A new study by Douglas Mental Health University Institute, Lachine, Qc. shows altered body rhythms of the hormone melatonin in Premenstrual dysphoric disorder (PMDD) women with insomnia. The main finding was that compared to healthy controls, PMDD women had significantly decreased melatonin secretion levels during the night-time hours.
This finding may help explain some of the sleep disruptions experienced by women with PMDD, also known as premenstrual syndrome.
Restless Leg Syndrome (RLS) often goes hand in hand with PMS symptoms. A condition that benefits significantly from the Magnesium Glycinate portion in our Magnesium Nighttime formulation.
The beneficial effects of therapeutic dosing of Magnesium Glycinate for migraine sufferers have been discussed in detail in the research tab of our regular Magnesium Glycinate product.
We also have quite a few testimonials from Migraine sufferers on our site.
But many migraineurs are susceptible to various environmental triggers that influence the secretion of melatonin from the pineal gland.  Melatonin levels have been found to be decreased in both migraine and cluster headaches sufferers.
Melatonin mechanisms are related to headache pathophysiology in many ways, including its anti-inflammatory effect, toxic free radical scavenging, reduction of pro-inflammatory cytokine upregulation, nitric oxide synthase activity and dopamine release inhibition, membrane stabilisation, GABA and opioid analgesia potentitation, glutamate neurotoxicity protection, neurovascular regulation, 5-HT modulation.
Interestingly, melatonin has also been studied as a treatment for other migraine co-morbidities, such as irritable-bowel syndrome. A paper published in 2005 showed that 88% of subjects reported mild-to-excellent improvement in IBS symptoms  when taking supplemental melatonin. This makes sense, given the strong correlation between migraine, abdominal migraine, infantile colic and irritable bowel syndrome .
Next to getting a good nights sleep,
the benefits from melatonin supplementation in these conditions seem promising and worth a try.